Prescription drugs (outpatient)

Medicare Part B (Medical Insurance)  covers a limited number of outpatient prescription drugs under certain conditions.

Usually, Part B covers drugs you wouldn't typically give to yourself, like those you get at a doctor's office or in a hospital outpatient setting .

Here are some examples of Part B-covered drugs:

  • Drugs used with an item of durable medical equipment (DME): Medicare covers drugs infused through DME, like an infusion pump or drugs given by a nebulizer, if the drug used with the pump is reasonable and necessary.
  • Some antigens: Medicare covers antigens if a doctor prepares them and a properly instructed person (who could be you, the patient) gives them under appropriate supervision.
  • Injectable osteoporosis drugs: Medicare covers injectable osteoporosis drugs if you meet all of these conditions:
    • You're a woman with osteoporosis who meets the criteria for the Medicare home health benefit.

    • You have a bone fracture that a doctor certifies was related to post-menopausal osteoporosis.

    • Your doctor certifies that you can’t give yourself the injection or learn how to give yourself the drug by injection.

In addition, Medicare will cover the home health nurse or aide to provide the injection if your family and/or caregivers are unable or unwilling to give you the drug by injection.

  • Erythropoiesis-stimulating agents: Medicare covers erythropoietin by injection if you have  End-Stage Renal Disease (ESRD)  or you need this drug to treat anemia related to certain other conditions.
  • Blood clotting factors: Medicare covers clotting factors you give yourself by injection, if you have hemophilia.
  • Injectable and infused drugs: Medicare covers most injectable and infused drugs when a licensed medical provider gives them, because these types of drugs aren't usually self-administered.
  • Oral End-Stage Renal Disease (ESRD) drugs: Medicare covers some oral ESRD drugs if the same drug is available in injectable form and the Part B ESRD benefit covers it.

Part B covers calcimimetic medications under the ESRD payment system, including the intravenous medication Parsabiv, and the oral medication Sensipar.

Your ESRD facility is responsible for giving you these medications. They can give them to you at their facility, or through a pharmacy they work with. You’ll need to work with your ESRD facility and your doctor to find out:

  • Where you’ll get these medications
  • How much you’ll pay
  • Parenteral and enteral nutrition (intravenous and tube feeding): Medicare covers certain nutrients if you can’t absorb nutrition through your intestinal tract or take food by mouth.
  • Intravenous Immune Globulin (IVIG) provided in home: Medicare covers IVIG if both of these conditions apply:
    • You have a diagnosis of primary immune deficiency disease.
    • Your doctor decides that it's medically appropriate for you to get the IVIG in your home.

Part B covers the IVIG itself, but doesn't pay for other items and services related to you getting the IVIG at home.

  • Shots (vaccinations): Medicare covers flu shots, pneumococcal shots, COVID-19 vaccinesHepatitis B shots for certain people, and some other vaccines when they’re related directly to the treatment of an injury or illness.
  • Transplant / immunosuppressive drugs. Medicare covers transplant drug therapy if Medicare paid for your organ transplant. You must have Part A at the time of the covered transplant, and you must have Part B at the time you get immunosuppressive drugs. Keep in mind, Medicare drug coverage (Part D) covers immunosuppressive drugs if Part B doesn't cover them. If you have Original Medicare, you may join a Medicare drug plan to get Medicare drug coverage. 
    If you only have Medicare because of End-Stage Renal Disease (ESRD), your Medicare coverage, including immunosuppressive drug coverage, ends 36 months after a successful kidney transplant. Medicare offers a benefit that may help you, if you lose Part A coverage 36 months after a kidney transplant, and you don’t have certain types of other health coverage (like a group health plan, TRICARE, or Medicaid that covers immunosuppressive drugs). This benefit only covers your immunosuppressive drugs and no other items or services. It isn’t a substitute for full health coverage. If you qualify, you can sign up for this benefit any time after your Part A coverage ends. To sign up, call Social Security at 1-877-465-0355. TTY users can call 1-800-325-0788.
  • Oral cancer drugs: Medicare covers some oral cancer drugs you take by mouth if the same drug is available in injectable form or the drug is a prodrug of the injectable drug. A prodrug is an oral form of a drug that, when ingested, breaks down into the same active ingredient found in the injectable drug. As new oral cancer drugs become available, Part B may cover them. If Part B doesn’t cover them, Part D does.
  • Oral anti-nausea drugs: Medicare covers oral anti-nausea drugs you use as part of an anti-cancer chemotherapeutic regimen if they’re administered before, at, or within 48 hours of chemotherapy or are used as a full therapeutic replacement for an intravenous anti-nausea drug.
  • Self-administered drugs in hospital outpatient settings: Under very limited circumstances, Medicare may pay for some self-administered drugs if you need them for the hospital outpatient services you're getting.

Your costs in Original Medicare

  • Doctors and pharmacies must accept assignment for Part B-covered drugs, so you should never be asked to pay more than the coinsurance or copayment for the Part B-covered drug itself. Beginning April 2023, your copay amount can change depending upon your prescription drug's price. In most cases, after you meet the Part B deductible , you pay 0% to 20% of the Medicare-Approved Amount  for covered Part B prescription drugs that you get in a doctor’s office or pharmacy, or in a hospital outpatient setting.
  • Starting April 1, 2023, you might pay a lower coinsurance amount for certain drugs and biologicals covered by Part B, if their prices have increased higher than the rate of inflation. The specific drugs and potential savings change every quarter.
  • If you get prescription drugs that Part B doesn’t cover in a hospital outpatient setting, you pay 100% for the drugs, unless you have Medicare drug coverage (Part D) or other drug coverage. In that case, what you pay depends on whether your drug plan covers the drug, and if the hospital is in your plan’s network. Contact your plan to find out what you pay if you get drugs in a hospital outpatient setting that Part B doesn’t cover.
  • You pay nothing (and the Part B deductible doesn't apply) for flu, pneumococcal, and Hepatitis B shots.
  • In 2023, you’ll pay a monthly premium of $97.10* and a $226 deductible if you sign up for the immunosuppressive drug benefit. Once you’ve met the deductible, you’ll pay 20% of the Medicare-approved amount for your immunosuppressive drugs. 

* You may pay a higher premium based on your income.


To find out how much your test, item, or service will cost, talk to your doctor or health care provider. The specific amount you’ll owe may depend on several things, like:

  • Other insurance you may have
  • How much your doctor charges
  • If your doctor accepts assignment
  • The type of facility
  • Where you get your test, item, or service


Things to know

Medicare drug coverage (Part D) covers drugs Part B doesn't cover. If you join a Medicare drug plan, check your plan's drug list (also called a  formulary ) to see what outpatient drugs it covers.

Part D generally covers all other recommended adult immunizations (like shingles, tetanus, diphtheria, and pertussis vaccines) to prevent illness. Talk to your provider about which ones are right for you. You can now get more vaccines under Part D at no cost to you. Contact your plan for details.